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These findings provide orthogonal validation of the results obtained by whole-genome bisulfite sequencing and establish array-based methylation profiling of CHO cells as a promising approach to optimize CHO cell culture conditions and to monitor or predict performance of the CHO cells during culturing

Our goal was to provide a strong mechanistic foundation by connecting chemistry and biology

Potential Research Applications: Appetite suppression and satiety studies Obesity and weight management models Metabolic health and insulin sensitivity research Dual pathway hormone modulation investigations For laboratory research use only

Mice were randomly allocated to experimental groups, and the investigator was blinded to the group allocation during the experiment