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This altered the conformation state of pyruvate kinase M2 (PKM2) from tetrameric to dimeric and thereby favored its nuclear translocation, where PKM2 phosphorylated the transcription factor signal transducer and activator of transcription 3 (STAT3) to increase pro-inflammatory IL-6 and IL-1 production (Shirai et al., 2016)

10.1016/j.addr.2021.113950 218 ShtykalovaS.EgorovaA.MaretinaM.BaranovV.KiselevA

Currently, approximately 40 million people worldwide are living with HIV 1 and two-thirds of these reside in Africa, where disease prognosis is poor due to limited access to high-quality healthcare and drugs

And more recently, prescription NAD+ therapies delivered via nasal spray, like Midi's NAD+ Nasal Spray, have emerged as an alternative to oral supplements and IV clinics