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To view or add a comment, sign in More Relevant Posts We are pleased to share our latest publication in Osteoarthritis and Cartilage Jourmal: A single intra-articular injection of JTA-004, a combination of human plasma, hyaluronic acid, and clonidine, versus placebo in symptomatic knee osteoarthritis: A Phase 3 trial Translating knowledge into clinical evidence is sometimes a long journeyespecially when results are not straightforward at first glance

IGF-1R activation after ligand binding activates AKT kinases/pathway linked to prevention of apoptosis and the ERK pathway associated with growth and proliferation

However, current studies have not established whether ferroptosis acts upstream in the cascade involving oxidative stress, astrocyte activation, and multimodal cell death

M.BrownL.AyyappanP.GR