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Another report also demonstrated that curcumin-loaded hyaluronan (HA)-modified ethosomes could target overexpressed CD44 protein and allowed the slow release of the loaded curcumin in the inflamed epidermis [209]

Additionally, in vitro studies using PC3 or DU145 cell lines showed that IGF-I regulates cell adhesion and motility that is needed for the formation of a pre-metastatic niche (144)