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The prevalence of CAN among diabetes patients ranges from 20 to 60%

Finally, the aforementioned rapid and successful recruitment of the blood vessels during harmful events suggests that the application of BPC 157 may offer a fundamental treatment by providing the cytoprotection/endothelium protection that is essential[2-8,12-16,20] to quickly restore blood supply to the ischemically injured area and rapidly activate collaterals during various harmful conditions such as vascular obstruction, short-lasting blood deprivation, reperfusion, long-lasting blood deprivation and additional bowel obstruction

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In colon epithelia, clostridium perfringens enterotoxin causes focal leaks by targeting claudins which are apically accessible due to tight junction derangement