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Participants received either a high-dose regimen (initial dose of 8,000 IU/day for two weeks, followed by 4,000 IU/day) or a standard-dose regimen (400 IU/day), in combination with mFOLFOX6 plus bevacizumab, continued until disease progression or unacceptable toxicity

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Mechanisms of reversible protein glutathionylation in redox signaling and oxidative stress