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In conclusion, this study provides strong evidence that curcumin exerts its anticancer effects in CRC by modulating the miR-134-5p/CDCA3/CDK1 axis, thereby suppressing tumor cell proliferation and invasion and promoting apoptosis ( 3.1.6 The Wnt/-catenin pathway The Wnt signaling pathways play a significant role in cancer development by modulating various processes such as cancer cell growth, differentiation, programmed cell death, cell cycle advancement, adhesion, and the formation of blood vessels ( in vitro experiments were carried out to determine if CUR affects this signaling or not ( in vivo , and analysis revealed that this effect was primarily due to the suppression of cell proliferation, rather than the induction of apoptosis

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Due to the heterogeneity of disparate symptoms in long-COVID patients, different mechanisms have been proposed, including viral persistence or reactivation, permanent inflammation, immune dysregulation, and alteration of gut microbiota, but there is not an adequate perception of this complex condition (Fernndez-de-Las-Peas et al., 2023)