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Unsupervised Cosmetic Use (CRITICAL WARNING): Its use as an unsupervised cosmetic tanning agent is highly discouraged by health authorities (FDA, TGA, HPRA) due to the unknown long-term risk of melanocytic proliferation and the development of new or atypical moles

Thus, an optimal flow velocity range of 400600 m/s has been found to favor both tumor cell arrest within vascular regions and endothelial remodelling, leading to extravasation and metastasis [229]

(14) Further studies using animal models have explored its effects under severe vascular and systemic stress conditions

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