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UV exposure, pollution, and inflammation all increase MMP activity, accelerating collagen destruction beyond normal aging rates

Additionally, purines function as metabolic signals and play crucial roles in the central nervous system, particularly in the functioning of neuronal and glial cells (Fumagalli et al., 2017)

Clinicians also may want to include multi-disciplinary assistance as appropriate, to manage as many factors as possible that appear to precipitate or exacerbate symptoms for each individual patient