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In global cerebral ischemia, the central part of the ischemic region does not receive any blood supply, but a small amount of blood can still reach this area through collateral circulation

Additionally, TLR4 regulates hippocampal neurogenesis and synaptic function through this pathway, and is involved in neuroinflammation and neuronal apoptosis (158)

Along with helping to reduce fatigue, carnosine also plays a lesser known and smaller role in breaking down and utilizing blood glucose during glycolysis for energy production during high intensity exercise [21]