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Coumarins are a class of benzopyrones, consisting of a benzene ring fused to an alpha-pyrone ring, also entailing important effects on human health and promising translational implications [555]

doi: 10.5851/kosfa.2016.36.4.476

Acacetin binds specifically to the ATP domain of HSP90, causing HSP90 to detach from COX-2, which leads to COX-2 being ubiquitinated and broken down in macrophages, thereby reducing inflammatory reactions (189)