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Hypothalamic-pituitary-adrenal axis defects Corticotropin-releasing factor can induce gastric stasis and vomiting by vagal stimulation

Cell Metab 37 , 857869 (2025)

The increased production of endothelin-1 and decreased production of nitric oxide in senescent endothelial cells lead to vascular inflammation and impaired vasodilation, compromise vascular endothelial integrity, and lead to vascular aging and atherosclerosis