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It helps determine whether there is DNA damage and, if there is, whether it can be repaired or if the cell with the abnormal DNA should be self-destroyed through apoptosis

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Use of low-tar cigarettes appears to reduce cardiovascular risk, further supporting a dose-response relationship 9

Among the remaining TCAs, amitriptyline is described as having the most pronounced serotonergic activity, but the cited guidance states that the combination of amitriptyline and an MAOI does not result in serotonin toxicity