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Curcumins array of biological activities stems from its anti-inflammatory activity, antioxidant properties, and induction of phase 2 detoxifying enzymes such as Heme Oxygenase (HO-1)

This toxic byproduct can wreak havoc on your organs, causing that pounding headache, nausea, sensitivity to light and sound, and overall fatigue we know all too well

Eur J Clin Pharmacol 30:331334

Lowering GSH levels also triggers ferroptosis through deactivation of GPX4, leading to accumulation of lipid peroxides [87] In some cases, GSH depletion alone can induce therapeutic effects without relying on Fenton chemistry, which typically involves HO reacting with Fe 2 to form hydroxyl radicals (OH) that damage critical biomolecules such as DNA, proteins, and lipids