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Specifically, leptin has been identified as a factor that induces MUC5AC expression by activating extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinases (MAPKs) ( MUC5AC and MUC5B expression through the ERK1/2, p38, and nuclear factor kappa B (NF-B) signaling pathways ( MUC5AC and MUC5B are associated with goblet cell metaplasia ( In summary, obesity is linked to a genetic predisposition and genes associated with airway remodeling

The discovery of G6PD crystal structures and subsequent analyses provided us with further insights into this enzyme deficiency, since specific mutations can now be plotted on a 3D position in the protein structure

Other data supporting the findings of this study are available at the European GenomePhenome Archive under code EGAS50000001113