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At least three biological replicates were tested per treatment

When it crosses the blood-brain barrier and binds to c-Met, it initiates synaptogenesis: new dendritic spines form, synaptic connections strengthen, and neurons that were alive but under-connected begin to integrate more fully into functional networks

Taken together, dysbiosis contributes to -cell dysfunction through three mutually reinforcing mechanisms: LPS/TLR4-mediated inflammation, insulin-resistancedriven -cell exhaustion, and reduced SCFA availability with consequent weakening of incretin signaling

Among these, glutathione (GSH), a tripeptide antioxidant, has demonstrated versatile and potent ROS-scavenging properties ( Graphene oxide (GO) has emerged as a promising nanoplatform due to its high surface area, rich surface chemistry, and excellent biocompatibility when properly functionalized ( Precise localization of nanocarriers to the injury site is crucial for therapeutic efficacy