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Dysfunction of the carnitine transporter OCTN2 is the cause of Primary Carnitine Deficiency (PCD), which is characterized by systemic loss of carnitine with severe clinical manifestations, including fertility issues in both males and females

The established Observed Safe Level (OSL) for chronic, long-term supplementation is generally recognized as 2,000 mg per day, though higher doses have been used safely in monitored trials

Yet, preterm infants appear to be especially vulnerable to adverse effects of -tocopherol supplementation, and supplemental vitamin E should be administered only under controlled supervision by a pediatrician (122)

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