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Rozycki HJ, Sysyn GD, Marshall MK, Malloy R, Wiswell TE

Reduced irritation may improve range of motion and exercise execution

Similarly, mTORC1 also regulates purine biosynthesis by regulating the levels of MTHFD2 (mitochondrial tetrahydrofolate cycle enzyme methylenetetrahydrofolate dehydrogenase 2) via the transcription factor ATF4 (cyclic AMP-dependent transcription factor ATF-4) (Duvel et al., 2010)