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doi: 10.1007/s10787-017-0309-4 42 JiaY.WangX.LiL.LiF.ZhangJ.LiangX

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Glutathionylated GRXs are subsequently reduced by a second molecule of GSH, which is recruited by the so-called activator site 13

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Moreover, it is noteworthy that nanotechnology offers immense potential in preventing and alleviating PIPN via two main strategies: 1) enhancing the targeting accumulation and/or activity of Pt drugs at tumor tissues while decreasing the off-target effects and 2) specific delivery of antioxidant agents toward the peripheral nervous system

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