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This in turn, first activates the PI3K/Akt/mTOR, PI3K/Akt/FoxO, or Ras/MAPK/(ERK-1/2) pathways that have important roles in cancer cell growth and carcinogenesis

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While ECD differences have important effects on ligand binding and some signalling events, the major differences in insulin and IGF-1 action are due to differences in the juxtamembrane ICDs of their receptors, especially in sequence difference at position 973 in this region of the IR and 951 in the IGF1R