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This data correlates well with previous work focusing on PC activation and purification from prothrombin complex concentrate (PCC) in which 5% w/w human thrombin to PC was incubated at 37 C for 3 h to achieve optimum APC generation 13

Weishaupt JH, Krtvlyessy P, Schumann P et al (2024) Tofersen decreases neurofilament levels supporting the pathogenesis of the SOD1 p.D91A variant in amyotrophic lateral sclerosis patients