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THF, in conjunction with serine, enters the 1C unit pool to participate in various biosynthetic reactions, including the interconversion of serine and glycine, de novo purine synthesis, thymidylate (dTMP) synthesis, and remethylation of homocysteine to methionine [36]

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In mouse models, cKO of Dnmt3b in the dorsal CA1 region impaired hippocampus-dependent recognition memory (Kong et al., 2020)

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