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The higher dietary fat intake (9weeks duration) of HFD-fed recipients did not result in differences in percent body weight gain, endocrine parameters (insulin, estradiol, and progesterone), and estrous cyclicity, relative to CD-fed recipients, indicating the preferential contribution of the local peritoneal environment rather than the systemic milieu to underlie the differences in lesion parameters

An explanation for this difference could be that fatigue in PCS increases with time

Schedlowski M, Engler H, Grigoleit JS