acetaminophen glutathione toxicity metabolism and NAPQI-mediated mitochondrial effects Too much paracetamol = dangerous
Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem acetaminophen hepatic glutathione Full article: Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, Acetaminophen overdose resulting in massive hepatic necrosis. Note the scant residual periportal hepatocytes. #liverpath #hepatology Does Acetaminophen Deplete Glutathione? Facts You Need to Know CYMBIOTIKA
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