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These landmark studies showed that mice with adipose-tissue-specific NNMT knockout remained lean when fed high-fat diets that caused wild-type mice to become obese, and that these protected mice had increased energy expenditure, enhanced fatty acid oxidation, improved glucose tolerance, and elevated NAD+ levels in adipose tissue

Notably, they exhibited lesser interstitial edema (only mild), markedly less damaged neurons than corresponding controls and had no inflammatory reaction ( Table 8 )