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Because biologic drugs (like adalimumab and infliximab) are large, complex proteins, the patient's immune system can sometimes recognize them as foreign and produce anti-drug antibodies against them

Additionally, we performed quantitative amino acid profiling of individuals from konzo-prone regions which suggests a deficiency in cystine, the precursor for the antioxidant glutathione, which is required by GPx3 to effectively remove ROS from circulation 22