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Drug class Angiotensin II Receptor Blocker (ARB) Mechanism of action Blocks AT receptors for angiotensin II Prevents: Vasoconstriction Aldosterone secretion Sodium and water retention Results in vasodilation and reduced blood pressure Clinical uses Hypertension Diabetic nephropathy Heart failure (alternative to ACE inhibitors) Stroke risk reduction in hypertension with LVH Pharmacokinetics Losartan itself is active Has an active metabolite (EXP-3174) which is more potent Hepatic metabolism (CYP2C9, CYP3A4) Once-daily dosing Important: Presence of an active metabolite does not make losartan a prodrug Adverse effects Dizziness Hyperkalemia Hypotension Rare: angioedema (less than ACE inhibitors) Contraindications Pregnancy Bilateral renal artery stenosis Losartan = Active drug Enalapril = Prodrug ARBs do NOT cause cough (unlike ACE inhibitors) To view or add a comment, sign in Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation

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3-phosphoglycerate (3-PG), the intermediate product of glycolysis, inhibits 6PGD enzyme activity