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Amelioration of Cyp7a1 and G6pc by fat transplantation in Insr P1195L/ +/HFD liver and suppression of Cyp7a1 by glycerol in wild-type mice suggest that suppressed hepatic expression of Cyp7a1 might well play a role in the regulation of glucose homeostasis in Insr P1195L/ +/HFD mice

Systemic inflammation has long been associated with cachexia, with various tumor secreted factors shown to correlate with as well as cause tissue wasting