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However, similar to GnRH agonist, GnRH antagonist is associated with hypoestrogenic adverse effects, which require the addition of estradiol and norethindrone acetate (add-back therapy) to attenuate the hypoestrogenic effect (Schlaff et al., 2020)

Outside of the Mdm2 binding motif, ~70% (47 out of 66) of the single substitutions maintained low nanomolar-affinity binding ( 90 M, Supplementary Table 1)

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Formally placing the substances on FDA's list of drugs that are safe for compounding would require new regulations, which can take months or years to draft