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SOD2) ( 2 O 2 , producing H 2 O and O 2 ( Intrinsic apoptosis is a form of programed cell death (RCD) initiated by a variety of microenvironmental perturbations, including (but not limited to) growth factor withdrawal, DNA damage, endoplasmic reticulum (ER) stress, reactive oxygen species (ROS) overload, replication stress, microtubular alterations, and mitotic defects ( Intrinsic apoptosis (type I cell death) ( Bcl-2 family proteins are subdivided into three groups on the basis of their pro- or anti-apoptotic action and Bcl-2 homology (BH) domains ( The mechanisms for the activation of pro-apoptotic Bcl-2 family members, such as Bax and Bad, have been well-studied

The onset of BBB dysfunction occurs with changes in the expression of functional membrane proteins and aggravating neuroinflammation

The librarian searched the following databases and trial registries from the date of inception through to October 24, 2024: PubMed (including pre-MEDLINE and non-MEDLINE

FP was calculated by measuring perpendicular and parallel fluorescence intensity values using the excitation and emission wavelengths of 482 nm and 530 nm, respectively, in a CLARIOstar microplate reader (BMG Labtech)