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Recently, an interesting study revealed that fructose at a high level triggered progressive glomerular injury by initiating ferroptosis and reported that mitochondrial single-strand DNA-binding protein 1 (SSBP1) is an important regulator in the glomeruli of high fructose-fed rats, as determined via quantitative proteomic analysis

Protein-sulfenic and glutathione sulfenic acids result from reaction with endogenously produced ROS or RNS but usually these species are rapidly transformed in prot-SSG (GSSR) or GSSG as more stable derivatives

doi: 10.1007/s13238-018-0549-0 196 WargoJ

Furthermore, ACSL4 has been identified as a key player in inhibiting glioma cell proliferation by activating apoptosis [43]