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Based on the data acquired from the blank samples, the ASV table was further modified by a sample decontamination step that was carried out with the package decontam (Davis et al., 2018) and 0.0088% of sequences were identified as potential contaminations and eliminated (i.e., DNA extraction blanks and experimental controls)

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Key Safety Differentiators No IGF-1 elevation: AOD-9604 does not stimulate IGF-1, meaning it avoids risks such as organ/tissue overgrowth or acromegaly No glucose disruption: Clinical data shows it does not impair insulin sensitivity or worsen blood sugar regulation Comparable to placebo: In obesity trials, the incidence of adverse effects was similar to placebo groups, underscoring its tolerability Legal Status of AOD-9604 United States: AOD-9604 is not FDA-approved as a drug, dietary supplement, or weight loss therapy