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Aspartame did not induce chromosomal aberrations in the bone marrow cells of C57BL/6 mice exposed at a dose of 40 or 400 mg/kg bw per day by oral gavage for 5 days (Durnev et al., 1995)

Thus, more than genes of major effect, evidence suggest that there are multiple susceptibility loci, each one with small effect

They do not

Moreover, studies linking the severity of bipolar symptoms to tardive dyskinesia, even in the absence of pharmacotherapy, lend further support to claims of dopamine dysfunction in this disease state (246)