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Currently, N -acetylcysteine (NAC) is clinically used as the main antidote for APAP poisoning, but its therapeutic effect remains limited owing to rapid disease progression and the general diagnosis of advanced poisoning

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Meanwhile, A oligomers also induce the hyperphosphorylation of the axonal microtubule-associated protein tau, which leads to the redistribution of tau into dendrites, where it disrupts the trafficking of glutamate receptors and thereby depresses neuronal excitation and function

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