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The formation and progression of cysts in ADPKD are also associated with oxidative stress, inflammation, and cell death (268, 269)

Doctors swear an oath to first, do no harm, and are expected to use treatments supported by evidence or, at minimum, a plausible expectation of benefit outweighing risks

A peptide may look promising in a lab dish or animal model, but clinical usefulness depends on whether the compound reaches the right tissue, stays stable long enough, and produces a meaningful benefit in real patients

Like other injectable weight-loss medications, cagrilintide follows a gradual dose-increase approach