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The uricosuric agents targeting the URAT1 transporter, such as lesinurad and dotinurad, along with the formulation of oral combination therapies comprising xanthine oxidase inhibitors and uricosuric agents, is poised to improve the attainment of the target serum uric acid level of less than 6 mg/dL

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This promotes the transcription of some of these genes and a de novo synthesis of the corresponding protective proteins, which in the liver, include glutathione-S-transferases (GSTs) [20]