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Copper serves as a cofactor for lysyl oxidase and lysyl hydroxylase, enzymes essential for collagen cross-linking and structural integrity

One study indicated that Nrf2 knockout may reduce Nrf2 entry into the nucleus and fail to initiate the transcription of downstream molecules, thereby exacerbating inflammation and autophagy in a severe pancreatitis induced acute lung injury model

Largely elevated levels of circulating IGF-I but as a result of absence of proteolysis of IGFBP-5 and IGFBP-3, necessary for disruption of ternary complex formation, IGF-I bioactivity in serum is low and presumably tissue bioactivity of IGF-I (and IGF-II) is low