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Increased levels of these metabolites are associated with increased expression of VCAM-1, and increased leukocyte adherence to vascular endothelium in mice, suggesting that an inflammation-dependent mechanism may underly the association of these metabolites with the development of major CV adverse events (Ferrell et al, 2024)

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It has shown promise in promoting bone growth, as evidenced by studies where its administration counteracted skeletal muscle catabolism induced by glucocorticoids and increased bone mineral content in rats