442 Targeting lactylation-related writers and erasers can modulate gene expression in cancer cells, inhibiting their proliferation and survival
In this process, LCFA must be first activated into lipoyl-CoA via acyl-CoA synthetase (ACS) (30)
doi: 10.1038/s41525-020-0123-6 75 MervoshN.DeviG
Rocha, Michael Aschner, Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies, Life Sci, 2012 Oct 10 [ 4 ] Lyn Patrick, Mercury toxicity and antioxidants: Part 1: role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity, Altern Med Rev 2002 Dec ( [ 5 ] Y W Lee, M S Ha, Y K Kim, Role of reactive oxygen species and glutathione in inorganic mercury-induced injury in human glioma cells, Neurochem Res, 2001 Nov ( [ 6 ] M L Queiroz, S C Pena, T S Salles, E M de Capitani, S T Saad, Abnormal antioxidant system in erythrocytes of mercury-exposed workers, Hum Exp Toxicol, 1998 Apr ( [ 7 ] R K Zalups, Molecular interactions with mercury in the kidney, Pharmacol Rev, 2000 Mar ( [ 8 ] Yasushi Honda, Takaomi Kessoku, Yoshio Sumida, Takashi Kobayashi, Takayuki Kato, Yuji Ogawa, Wataru Tomeno, Kento Imajo, Koji Fujita, Masato Yoneda, Koshi Kataoka, Masataka Taguri, Takeharu Yamanaka, Yuya Seko, Saiyu Tanaka, Satoru Saito, Masafumi Ono, Satoshi Oeda, Yuichiro Eguchi, Wataru Aoi, Kenji Sato, Yoshito Itoh, Atsushi Nakajima, Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study, PubMed, 2017 Aug ( [ 9 ] Dipali Pathak, Correcting glutathione deficiency improves impaired mitochondrial fat burning, insulin resistance in aging, April 2, 2013, Baylor College of Medicine ( [ 10 ] Enrico Arosio, MD, Sergio De Marchi, MD, Massimo Zannoni, MD, Manlio Prior, MD, Alessandro Lechi, MD, Effect of Glutathione Infusion on Leg Arterial Circulation, Cutaneous Microcirculation, and Pain-Free Walking Distance in Patients With Peripheral Obstructive Arterial Disease: A Randomized, Double-Blind, Placebo-Controlled Trial, Aug 2002 ( [ 11 ] Michelle Smeyne, Richard Jay Smeynecorresponding, Glutathione Metabolism and Parkinsons Disease, PubMed, 2013 May 8 ( [ 12 ] Janet K
