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Keywords: chondrocyte, senescence, autologous chondrocyte implantation, senolytic, FOXO4-DRI Introduction Autologous chondrocyte implantation (ACI) is a biomedical treatment that repairs cartilage injury in the knee joint, which has been shown to reduce pain and facilitate mobility recovery (Kreuz et al., 2019)

Although the mechanism of how ADSC-CM promotes skin regeneration is unclear, ADSC-CM contained various growth factors and it is an excellent raw material for skin treatment

The bioregulator peptide approach of modulating existing biological pathways rather than forcing artificial responses distinguishes PTD-DBM from many conventional treatments