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Structural Basis for Achieving GSK-3beta Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery

Maintaining proper hydration is crucial for overall comfort and healing

A TDS3032C 300 MHz Digital Phosphor Oscilloscope (Tektronix) and TGP110 10 MHz Pulse Generator with Delay (Thurlby Thandar Instruments) were used to generate a 100 ms LED (Thorlabs Inc.) pulse at either 530 nm (green light) or 660 nm (red light)

Further analysis revealed that magnoflorine inhibited Keap1 expression, which in turn promoted Nrf2 nuclear translocation and downstream HO-1 expression