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This happens because prostacyclin analogs cause blood vessel dilation throughout the body, including blood vessels in the head

doi: 10.1152/japplphysiol.00652.2016 Summary Keywords stress, corticosterone, immunity, inflammation, mechanism Citation Xu J, Wang B and Ao H (2025) Corticosterone effects induced by stress and immunity and inflammation: mechanisms of communication

The chronic activation of apoptotic pathways can lead to alterations in neurotransmitter systems, including serotonin and dopamine, both of which are critically involved in mood regulation

This is important because oxidative damage is a major source of cellular aging and UV skin damage