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Polyneuropathy has been associated with lipodystrophic disorders, but the neuropathy reported so far in patients with CGL1 were classically less severe, mainly with sensitive symptoms like pain and paresthesia in the limbs

The program established a favorable safety profile but the Phase IIb endpoint did not differentiate sufficiently from placebo to support continued development for obesity

[12] According to a patent, "Short duration safety studies with dihexa have uncovered no apparent toxicity