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Overall, this study advances mechanistic understanding of Pb toxicity in phototrophs by explicitly linking metal accumulation patterns with oxidative stress dynamics and metabolic adaptation in a comparative framework

Targeting the BCAAs transporter SLC7A5 with JPH203 inhibited oxidative phosphorylation and exerted anti-leukemic effects, suggesting that the GPRC5C-SLC7A5-BCAAs axis may serve as a therapeutic target (Zhang Y