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Prior studies suggest that there is an association between stress from early adverse life events and the development of irritable bowel syndrome (IBS), a functional disorder associated with a higher intestinal permeability [93, 94]

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Bischoff SC, Barbara G, Buurman W et al (2014) Intestinal permeabilitya new target for disease prevention and therapy

Oxidants = reactive oxygen species (ROS) / free radicals Antioxidants = molecules that neutralise ROS by donating electrons This is fundamentally a REDOX imbalance Free radicals are electron-deficient molecules that: Steal electrons from healthy cells Trigger chain reactions of oxidation Damage: Cell membranes (lipid peroxidation) Proteins (enzyme dysfunction) DNA (accelerated ageing, impaired repair) In SKIN, this translates to: Fine lines & wrinkles Loss of elasticity Pigmentation irregularities Impaired barrier function Chronic inflammation UV radiation ( primary extrinsic ageing factor ) Pollution & cigarette smoke Inflammation (acne, rosacea, dermatitis) Poor sleep & psychological stress Aggressive aesthetic treatments without adequate antioxidant support Antioxidants donate electrons without becoming unstable themselves, effectively terminating free-radical chain reactions and reducing OXIDATIVE STRESS