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Specifically, overexpressing SIRT2 didnt affect the acetylation level of GCLC (Fig

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In particular, the dynamic changes in mitochondrial number observed in WT livers, characterized by an early decrease at 2 hours, followed by partial recovery at 6 hours and a subsequent decline at 24 hours, were blunted in HuR Hep-/- livers, suggesting impaired mitochondrial remodeling in response to APAP-induced stress

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