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Effect of extended intraocular pressure elevation on optic nerve head and axonal transport

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Primary hypothyroid patients usually feel best, and/or obtain the best symptom or physiological test scores on T4 and/or T4/T3 regimens that produce a low or suppressed TSH (Cooke, Escobar-Morreale, Appelhof)

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Another piece of this is that when opioids are more affordable, less people using them come up short of their habit, resulting in oscillating between getting dopesick and getting well, which is another example of something that lowers tolerance, just like treatment or jail, therein raising OD risk

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