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Physician type: Surgical oncologist ANZSRC Categories: 1112 Oncology and Carcinogenesis RCDC Category: Lung Cancer Keywords : lung, cancer, smoking, cigarettes, negative, trastuzumab, expression, resistance, factor, prognostic, metastasis Table of Contents Research Papers Head to head evaluation of second generation ALK inhibitors brigatinib and alectinib as first-line treatment for ALK+ NSCLC using an in silico systems biology-based approach DOI: 10.18632/oncotarget.27875 Abstract | PDF | Full Text | Supplementary Files | Altmetric Report Around 37% of patients with non-small cell lung cancer (NSCLC), which represent 85% of diagnosed lung cancers, have a rearrangement in the ALK gene that produces an abnormal activity of the ALK protein cell signaling pathway

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Apoptotic stimuli were shown to regulate Bcl-2 stability via affecting the ubiquitination-dependent protein degradation (Dimmeler et al, 1999