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Cannabis Withdrawal Syndrome Experiencing three or more of these symptoms is dubbed cannabis withdrawal syndrome. The symptoms may be mild or severe, but they do dissipate over time

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[200] [199] Depending on the protein kinase involved and the residue(s) phosphorylated, phosphorylation can shift transporter function into an efflux-permissive state that causes the reverse transport of cytosolic monoamines into the synaptic cleft, or it can promote transporter internalization, whereby phosphorylated transporters are withdrawn from the plasma membrane and lower total reuptake capacity (i.e., non-competitive reuptake inhibition)