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It also means allergic reactions are unlikely, though not impossible, since any foreign substance can theoretically trigger sensitivity in susceptible individuals

If you have a history of B12 deficiency, malabsorption issues, or are vegetarian/vegan with marginal B12 status, the weekly B12 injection provides protection during the high-risk period of rapid weight loss

(Study: Davies et al., 2021) Administration: Tirzepatide is administered as a once-weekly subcutaneous injection, maintaining the convenience and efficacy observed in similar medications

In April 2015, another study was published in CMAJ Open that linked PPIs to a threefold increase in the risk of developing acute interstitial nephritis and a higher risk of acute kidney injury in older adults as compared to their peers who did not take the medicines